1. Mitral valve disease (from Cavalier line)
Source dated 2024PLOS One 2024 study: designer-crossbreeds do not have poorer health than parent breeds. Cavoodles inherit Cavalier cardiac risk; prevalence lower than pure Cavaliers but still significant.
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0306350