1. Hypertrophic cardiomyopathy (HCM)
Source dated accessed 2026-05-20Maine Coons carry the autosomal-dominant A31P mutation in the MYBPC3 gene, found in approximately 26% of the breed. Homozygous cats (two copies) risk moderate-to-severe disease by age 4; heterozygous cats have longer life expectancy but may still develop HCM. DNA testing is available.